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. Author manuscript; available in PMC: 2018 Mar 1.
Published in final edited form as: Hypertension. 2017 Jan 30;69(3):387–395. doi: 10.1161/HYPERTENSIONAHA.116.08316

Figure 3. Alterations in renin cell fate lead to disease.

Figure 3

Conditional deletion of key molecules within renin cells results in in cell fate change leading to renal and systemic pathology. B-RcKO, deletion of the beta-adrenergic receptor; Cx40, connexin 40; VHL, Von Hippel Lindau gene; RBP-J, recombination signal binding protein for immunoglobulin Kappa J. CBF1, human homolog of RBP-J.