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. Author manuscript; available in PMC: 2017 Jul 13.
Published in final edited form as: Endocrine. 2016 Aug 11;55(3):702–711. doi: 10.1007/s12020-016-1072-9

Table 3.

Summary of the evidence quality grading using GRADE

Outcome Quality assessment Effect

No. of studies Study design Risk of bias Inconsistency Indirectness Imprecision Other onsiderations SMD (95 %CI) Quality
Sleep quality overall 8 RCT Seriousa Not serious Not serious Seriousb Seriousc −0.12 (−0.36, 0.13) ⊕⊕○○Low
Sleep quality VMS subgroup 3 RCT Seriousa Not serious Not serious Not serious Seriousc −0.54 (−0.91, −0.17) ⊕⊕⊕○Moderate

The GRADE working group grades of evidence are as follow: 1. High quality, future research is very unlikely to change the group’s confidence in the estimate of effect; 2. Moderate quality, further research is likely to have an important impact on the group's confidence in the estimate of effect and may change the estimate; 3. Low quality, further research is very likely to have an important effect on the group’s confidence in the estimate of effects and is likely to change the estimate; 4. Very low quality, the group is very uncertain about the estimate

a

The quality was downgraded because there was overall poor reporting of blinding and allocation concealment

b

Wide confidence intervals in our estimate effect limit conclusions

c

Large numbers of studies do not contribute to sleep quality outcome, suggesting possible reporting bias

CI confidence interval, SMD standardized mean difference