Table 1. Effects of Specific DAergic and NErgic Drugs on Pyramidal Cell Properties.
Treatment | MP (mV) | IR (MΩ) | Number of spikes/pulse | ||||||
---|---|---|---|---|---|---|---|---|---|
|
|
|
|||||||
Control | Treatment | Control | Treatment | Control | Treatment | ||||
Control–MPH (10 μM, n = 30) | 72.3 ± 0.2 | 72.2 ± 0.1 | 463.3 ± 47.8 | 435.0 ± 48 | 3.9 ± 0.3 | 5.1 ± 0.5* | |||
Control–MPH (1 μM, n = 10) | 71.3 ± 0.8 | 71.2 ± 0.4 | 359.2 ± 27.2 | 402.1 ± 37.8 | 2.8 ± 0.3 | 2.7 ± 0.6 | |||
Control–MPH (reserpine) | 70.1 ± 0.6 | 69.4 ± 0.5 | 4.0 ± 0.7 | 4.3 ± 0.9 | |||||
Control–prazosine–MPH | 73.0 ± 0.1 | 73.5 ± 0.4 | 72.7 ± 0.2 | 445 ± 41.2 | 429.3 ± 40.3 | 405.4 ± 53.1 | 2.8 ± 0.2 | 3.9 ± 0.5 | 4.9 ± 0.9** |
Control–yohimbine–MPH | 72.9 ± 1.1 | 72.2 ± 1.9 | 72.3 ± 1.2 | 488.2 ± 82 | 439.8 ± 59.5 | 527.4 ± 60 | 3.4 ± 0.4 | 3.7 ± 0.5 | 3.2 ± 0.8 |
Control–propanolol–MPH | 71.8 ± 2.5 | 71.8 ± 2.1 | 71.9 ± 2.0 | 423.4 ± 41.1 | 267 ± 92.9 | 420 ± 50.8 | 4.2 ± 0.8 | 5.2 ± 1.5 | 5.1 ± 1.4 |
Control–SKF 38390–MPH | 72.3 ± 0.1 | 72.6 ± 0.2 | 71.9 ± 0.2 | 345.1 ± 64 | 232 ± 85 | 327 ± 81.1 | 3.1 ± 0.3 | 3.7 ± 0.7 | 5.4 ± 0.9*** |
Control–clonidine | 71.8 ± 0.4 | 72.1 ± 0.3 | 575.3 ± 56.9 | 418.9 ± 62.7 | 3.4 ± 0.6 | 6.1 ± 0.7**** |
Bold values indicate significant changes.
p<0.0007.
p<0.01.
p<0.03.
p<0.000005.