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. 2017 May 10;5(2):E373–E385. doi: 10.9778/cmajo.20160066

Table 1: Characteristics of the included reviews.

Condition; author Search date Country No. of included studies Included design Population
(adult or children)		 Duration Indication Immunotherapy evaluated Type of analysis Included allergens AMSTAR score*
Allergic asthma
Liao et al.,16 2015 February 2014 China 11 RCT Children 4 mo-3 yr AA SLIT Meta-analysis House dust mite 7
Normansell et al.,17 2015 March 2015 UK 52 RCT Mixed 1 d-3 yr AA ± AR SLIT Meta-analysis House dust mite, grass pollen, birch pollen, cockroach, cat, Alternaria, Parietaria, Artemisia, olive pollen 11
Lu et al.,18 2015 February 2013 China 19 RCT Mixed 4 mo-3 yr AA SCIT Meta-analysis House dust mite 7
Tao et al.,19 2014 March 2012 China 16 RCT Mixed 10 wk- 25 mo AA ± AR ± conjunctivitis SLIT Meta-analysis House dust mite, grass, birch pollen 6
Abramson et al.,1 2010 August 2005 Australia 88 RCT Mixed ≤ 3 yr AA SCIT Meta-analysis House dust mite, pollen, animal dander, mould, latex 7
Allergic rhinitis
Yang et al.,20 2016 April 2016 China 4 RCT Mixed 7-20 mo AR SLIT Meta-analysis Cedar pollen 7
Di Bona et al.,21 2015 April 2014 Italy 13 RCT Mixed 12 wk-1 yr AR ± AA SLIT Meta-analysis Grass pollen 8
Seidman et al.,3 2015 November 2013 US 267 CPG, SR, RCT Mixed NR Seasonal and perennial AR SCIT, SLIT Narrative NR 0
CADTH,22 2014 June 2014 Canada 8 RCT Mixed 9 wk-2 yr Seasonal AR ± conjunctivitis SCIT, SLIT Network meta-analysis Grass pollen 7
Feng et al.,23 2014 May 2013 China 9 RCT Mixed 2.3 mo-3 yr AR SCIT (cluster) Meta-analysis Grass pollen, cat hair 8
Devillier et al.,24 2014 2013; mo NR France 28† RCT Mixed NR Seasonal AR SLIT Meta-analysis Grass pollen 5
Dranitsaris et al.,25 2014 December 2012 Canada 20 RCT Mixed 1-34 mo Seasonal AR SCIT, SLIT Meta-regression Grass pollen 3
Larenas-Linnemann et al.,26 2013 December 2012 Mexico 28 RCT, NRS Children,  adolescents 6 mo-3 yr AR or RC ± AA SLIT Narrative Grass or tree pollen, house dust mite, Alternaria, peanut, milk 6
Lin et al.,27 2013 (Kim et al., 2013, Erekosima et al., 2014, Lin et al., 2013, Chelladurai et al., 2013) May 2012 US 142‡ RCT Mixed NR Allergic RC ± AA SCIT, SLIT Narrative Pollen, cat, dog, cockroach, house dust mite 11
Manzotti et al.,28 2013 January 2012 Italy 7 RCT Mixed 5.3-7 mo Seasonal allergic RC SLIT Narrative Grass pollen 1
Meadows et al.,29 2013 (Dretzke et al., 2013) April 2011 UK 28 RCT Mixed Mean 3.6 yr AR ± AA SCIT, SLIT Meta-analysis Grass, tree or ragweed pollen, Alternaria, Parietaria 10
Calderón et al.,6 2013 March 2013 UK 44 RCT Mixed 6-28 mo AR and AA SCIT, SLIT Narrative House dust mite 3
Purkey et al.,30 2013 December 2011 US 12 RCT NR ≤ 5 yr Seasonal and perennial AR SCIT, SLIT Narrative Pollen 3
Calderón et al.,31 2011 January 2011 UK 42 RCT Mixed 3-36 mo Seasonal and perennial ARC or conjunctivitis SLIT Meta-analysis Pollen 11
Larenas-Linnemann et al.,32 2011 April 2011 Mexico 31§ RCT, NRS Children and adolescents 3-36 mo Seasonal or perennial AR or RC ± AA SCIT Narrative House dust mite, grass pollen, birch, fungus 5
Radulovic et al.,33 2010 (Wilson et al., 2009) August 2009 UK
 60 RCT Mixed 2 wk-3 yr¶ Seasonal and perennial AR SLIT Meta-analysis Parietaria, ragweed, tree pollen, house dust mite, cat 10
Bousquet et al.,2 2011 June 2009 France 94 RCT Mixed NR AR conjunctivitis, ± AA SCIT, SLIT Narrative
 Grass pollen 2
Calderón et al.,34 2010 January 2009 UK 33 RCT Mixed 1-84 mo Seasonal ARC SCIT, SLIT Narrative Grass pollen 1

Note: AA = allergic asthma, AR = allergic rhinitis, ARC = allergic rhinoconjunctivitis, CADTH = Canadian Agency for Drugs and Technologies in Health, CPG = clinical practice guideline, NR = not reported, NRS = nonrandomized study, RC = rhinoconjunctivitis, RCT = randomized controlled trial, SCIT = subcutaneous immunotherapy, SLIT = sublingual immunotherapy, SR = systematic review, UK = United Kingdom, US = United States.

*Maximum 11.

†Authors reported that 28 publications were included; unclear whether this represents the number of unique RCTs.

‡Authors reported that 142 articles were included; unclear whether this represents the number of unique RCTs.

§Authors reported that 31 articles were included; unclear whether this represents the number of unique RCTs.

¶Three consecutive grass pollen seasons.