Table 2. Pooled event rates of drug resistant tuberculosis among newly-diagnosed TB patients, Nigeria.
| Variables | Sub-group | Pooled event rate % (95% CI) | n/N | No. of Studies | Heterogeneity I2 (P -value) |
|---|---|---|---|---|---|
| Any drug resistance | Total | 32.0 (24.0–40.0) | 734/2892 | 23 | 98.3 (<0.001) |
| Stratified by DST | |||||
| Genotypic | 12.0 (6.0–18.0) | 87/1174 | 6 | 94.8 (<0.001) | |
| Phenotypic | 37.0 (22.0–52.0) | 647/1808 | 17 | 98.4 (<0.001) | |
| Stratified by regiona | |||||
| North | 21.0 (15.0–28.0) | 179/1538 | 10 | 95.6 (<0.001) | |
| South | 36.0 (21.0–51.0) | 296/1087 | 12 | 97.0 (<0.001) | |
| Mono-drug resistance | Total | 13.0 (10.0–17.0) | 199/2002 | 20 | 89.9 (<0.001) |
| Stratified by DST | |||||
| Genotypic | 11.0 (4.0–18.0) | 44/694 | 4 | 94.7 (<0.001) | |
| Phenotypic | 13.0 (10.0–17.0) | 155/1308 | 16 | 64.6 (0.001) | |
| Stratified by regiona | |||||
| North | 12.0 (0.07–0.17) | 76/947 | 8 | 90.0 (<0.001) | |
| South | 16.0 (13.0–18.0) | 103/698 | 11 | 0 (0.90) | |
| Multidrug resistance | Total | 6.0 (4.0–8.0) | 161/2502 | 21 | 86.1 (<0.001) |
| Stratified by DST | |||||
| Genotypic | 4.0 (0.0–8.0) | 25/694 | 4 | 82.5 (<0.001) | |
| Phenotypic | 7.0 (4.0–10.0) | 136/1808 | 17 | 86.2 (<0.001) | |
| Stratified by regiona | |||||
| North | 3.0 (1.0–5.0) | 55/1447 | 9 | 77.5 (<0.001) | |
| South | 12.0 (7.0–18.0) | 88/698 | 11 | 87.2 (<0.001) |
DST = drug susceptibility testing method; TB = tuberculosis;
a = studies from multiple regions excluded