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. 2017 Jul 13;12(7):e0181003. doi: 10.1371/journal.pone.0181003

Fig 6. Effects of PMPs on the expression and activation of Erk and Akt in RA-FLSs.

Fig 6

(A and B) Protein levels of p-Erk, Erk, Akt and p-Akt were analyzed from PMPs-treated RA-FLSs with corresponding antibodies. Quantification analysis was shown and expressed as fold-change. (*p < 0.05 vs. 0 μg/ml PMPs) (C) Quantification of the migration assay of RA-FLSs with PMPs and PD98059 was shown. (*p < 0.05 vs. PMPs) (D and E) Western blotting was performed to detect Erk, p-Erk, IκB, p- IκB, NF-κB and p- NF-κB of RA-FLSs after treated with PMPs and PD98059. (*p < 0.05 vs. PMPs) (F)RT-qPCR was conducted to detect the expression of MMP1 in RA-FLSs after treated with PMPs and PD98059. (*p < 0.05 vs. PMPs).