Table 6. The database/tissue/disease filters can significantly reduce the number of predicted common targets but still keep the functional common target of a set of miRNAs.
| A set of human miRNAs | Common target gene | Reference Pubmed ID | Filter settings: (database/tissue/disease) | # of predicted targets when using the filters |
|---|---|---|---|---|
| miR-17-5p, miR-19a-3p, miR-20a-5p, miR-20b-5p, miR-26b-5p, miR-106a-5p, miR-106b-5p | PTEN | 22000013 | 3 / prostate tissue / prostate carcinoma | 20 |
| miR-186-5p, miR-216b-5p, miR-337-3p, miR-760 | CSNAK2A1 | 23137536 | 3 / colon / colorectal carcinoma | 23 |
| miR-330-3p, miR-608, miR-216a-5p | CD44 | 21149267 | 2 / breast tissue / breast neoplasms | 78 |
| miR-130a-3p, miR-301a-3p, miR-454-3p | SMAD4 | 23393589 | 3 / colon / colorectal neoplasms | 116 |
| miR-19b-3p, miR-20a-5p | PTEN | 20577206 | 3 / colon tissue / colon carcinoma | 91 |