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. Author manuscript; available in PMC: 2017 Jul 13.
Published in final edited form as: Front Biosci (Landmark Ed). 2017 Jan 1;22:558–569. doi: 10.2741/4502

Figure 4.

Figure 4

TGF-β-mediated induction of collagen I was promoted by CD38-deficiency or inhibition of lysosomal functions. TGF-β increased the collagen I protein content significantly, which was more markedly in cells with deficiency of CD38 gene (A, B). The effects of TGF-β on collagen I levels were enhanced by inhibition of lysosomal functions using Baf (C, D). Shown are representative Western blot gel (A and C) and the densitometric analysis from studies with CAMs from 4 mice (B and D). * P<0.0.5 compared to untreated CD38+/+ samples, # P<0.0.5 compared to TGF-β treated CD38+/+ samples.