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The angles of the orientation vectors A, B, and C with respect to the bilayer normal are shown as violet, green and light blue, respectively. Simulations run from 0 to 300 ns, with 20% DMPS (Panel A), 10% PIP2 (Panel B), and 10% DMPS + 3% PIP2 membranes (Panel C) for the starting orientations OR1 and OR2. The rightmost figure in each panel shows the distance of the KRas4b center-of-mass from the bilayer center for OR1 (dark blue) and OR2 (red) for each membrane composition. (See text)
