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. Author manuscript; available in PMC: 2017 Jul 13.
Published in final edited form as: J Mol Cell Cardiol. 2015 Jan 29;83:142–155. doi: 10.1016/j.yjmcc.2015.01.011

Fig. 5.

Fig. 5

SIRT1 regulation by miRNAs in ECs. miR-217 downregulates SIRT1 expression. This leads to lower deacetylation of its targets FOXO1 and eNOS, rendering them inactive and triggering senescence (left). By targeting SIRT1 expression, miR-132 decreases SREBP-1c acetylation and increases its activity, promoting the accumulation of fatty acids and cholesterol (center). In TGF-β-treated ECs, miR-212 reduces SIRT1 abundance, inhibits endothelial migration and capillary tube formation, and stimulates Notch signaling via NRARP (right).