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. Author manuscript; available in PMC: 2017 Jul 13.
Published in final edited form as: J Mol Cell Cardiol. 2015 Jan 29;83:142–155. doi: 10.1016/j.yjmcc.2015.01.011

Fig. 6.

Fig. 6

SIRT1 regulation by miRNAs in cardiomyocytes. In cardiomyocytes, the free fatty acid palmitate increases miR-195 levels, which in turn inhibits SIRT1 and promotes ROS-triggered apoptosis (left). In hypoxic cardiomyocytes, downregulation of miR-199a increases HIF-1α levels and p53-mediated cardiomyocyte apoptosis (center). In normoxic cardiomyocytes, low miR-199a raises SIRT1 and HIF-1α levels, simulating preconditioning (right).