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. Author manuscript; available in PMC: 2018 Aug 1.
Published in final edited form as: Eur J Pain. 2017 Mar 20;21(7):1209–1223. doi: 10.1002/ejp.1021

Figure 5. Acute administration of ion channel antagonists.

Figure 5

(A) Local injection of the P2X7 receptor antagonist A438079 resolved mechanical hypersensitivity in TNFR1/R2−/− mice only at the 30 min time point post injection. Mechanical withdrawal thresholds and (B) response latencies in the hotplate test were significantly increased and then returned to their hypersensitive levels. (C) Local injection of the NMDA receptor antagonist MK801 in TNFR1/R2−/− mice significantly increased mechanical withdrawal thresholds for up to 3 h post injection (P < 0.05). (D) Response latencies of TNFR1/R2−/− mice in the hotplate test were significantly attenuated only at 30 min post injection. (E) Local administration of the TRPV1 antagonist capsazepine had no effect on mechanical withdrawal threshold or (F) heat response latencies. None of the compounds tested altered the responses of WT animals (# P < 0.05 between timepoints; * P < 0.05 between groups).