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. Author manuscript; available in PMC: 2017 Sep 20.
Published in final edited form as: Oncogene. 2017 Mar 20;36(28):4060–4071. doi: 10.1038/onc.2017.16

Figure 1. DSS induced colitis activates colonic CAMK2γ via non-canonical WNT signaling.

Figure 1

(A) Scheme for colitis induction. Red color indicates the duration of DSS treatment. (B) Protein expression and phosphorylation of CAMK2γ in DSS-induced colitis. The relative expression levels normalized to GAPDH were shown under the blot. They were further quantified and shown as bar plots. (C) The relative mRNA expression profile of WNT ligands in the colonic tissue of H2O- or DSS-treated mice. Expression levels were normalized to H2O-treated mice. (D) Expression of WNT family ligands in a UC patient microarray cohort. (E) Effects of retroviral over-expression of WNT5A in cell lines on CAMK2γ phosphorylation. DOX = doxycycline. (F) Phosphorylation of CAMK2γ by WNT5A in response to intracellular calcium chelator (BAPTA/AM) treatment. Results are presented as mean ± s.e.m. of 3 independent experiments; *P<0.05. See also Supplementary Fig. 1.