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a. Pattern of intermittent hypoxia. There are 6 decreases to ~ 6% per hour alternating with an hour of normoxia, 24 hours/day, 7 days/week. Each decrease lasts ~ 3 minutes resulting in 72 hypoxia events per day. b. Decreases in chamber oxygen concentration (CHO2), oxyhemoglobin saturation (SaO2) and associated increases in heart rate (HR) with each decrease. c. Timeline for the intermittent hypoxia (IH) exposure, biomarkers of acute injury and DTI/MRS protocols.
