Table 2.
Metabolite concentration changes that were significant or had P values of ≤ 0.08 following exposure to intermittent hypoxia
| Metabolite | Brainstem | Hippocampus | ||||||
|---|---|---|---|---|---|---|---|---|
| RA | IH | P | RA | IH | P | |||
| Cr | 3.94 ± 0.54 | 3.04 ± 1.37 | 0.030 | ↓ | 4.12 ± 1.29 | 4.00 ± 1.72 | 0.880 | |
| pCr | 2.63 ± 1.39 | 3.40 ± 0.95 | 0.220 | 4.55 ± 1.50 | 4.68 ± 1.17 | 0.870 | ||
| TCr | 4.97 ± 2.37 | 7.16 ± 1.04 | 0.030 | ↑ | 8.67 ± 1.76 | 8.67 ± 1.30 | 1.00 | |
| NAA/Cho | 8.90 ± 3.18 | 5.87 ± 2.07 | 0.042 | ↓ | 12.81 ± 5.59 | 7.62 ± 2.83 | 0.037 | ↓ |
| Naa/Cr | 2.40 ± 1.45 | 1.43 ± 0.39 | 0.080 | ↓ | 1.94 ± 0.49 | 1.46 ± 0.47 | 0.080 | ↓ |
| NAAG/Cr | 1.59 ± 1.39 | 0.71 ± 0.27 | 0.080 | ↓ | 0.45 ± 0.23 | 0.42 ± 0.62 | 0.910 | |
| TNAA/Cr | 3.99 ± 2.61 | 2.14 ± 0.57 | 0.060 | ↓ | 2.40 ± 0.60 | 1.88 ± 0.42 | 0.070 | |
| NAA | 4.07 ± 1.30 | 5.20 ± 0.91 | 0.070 | ↑ | 5.90 ± 1.87 | 7.29 ± 1.99 | 0.190 | |
| TCho | 0.84 ± 0.28 | 1.57 ± 0.37 | 0.001 | ↑ | 1.47 ± 0.42 | 1.12 ± 0.25 | 0.090 | |
| pCho | 0.35 ± 0.20 | 0.59 ± 0.24 | 0.060 | ↑ | 0.64 ± 0.33 | 0.59 ± 0.25 | 0.740 | |
| GPC | 0.49 ± 0.09 | 0.98 ± 0.31 | 0.010 | ↑ | 0.83 ± 0.22 | 0.53 ± 0.39 | 0.080 | ↓ |
| Tau/Cr | 1.93 ± 1.16 | 0.93 ± 0.29 | 0.030 | ↓ | 2.55 ± 1.17 | 2.54 ± 0.64 | 0.980 | |
| Gly | 3.94 ± 0.54 | 3.87 ± 1.36 | 0.900 | 1.75 ± 0.98 | 3.05 ± 1.03 | 0.030 | ↑ | |
| Gly/Cr | 2.64 ± 2.10 | 1.02 ± 0.30 | 0.040 | ↓ | 0.56 ± 0.45 | 0.79 ± 0.38 | 0.290 | |
| GABA/Cr | 2.53 ± 1.71 | 1.28 ± 0.69 | 0.070 | ↓ | 1.37 ± 0.65 | 1.22 ± 0.37 | 0.580 | |
| Glc/Cr | 0.72 ± 0.76 | 0.20 ± 0.25 | 0.070 | ↓ | 0.20 ± 0.24 | 0.23 ± 0.18 | 0.760 | |
| Ins/Cr | 3.47 ± 2.87 | 1.71 ± 0.67 | 0.080 | ↓ | 1.02 ± 0.59 | 0.92 ± 0.33 | 0.700 | |
Cr (creatine), p (phosphoryl), T (total), NAA (N-acetylaspartate), Cho (choline), GPC (glycerophosphocholine), Tau (taurine), Gly (glycine), GABA (λ-aminobutyric acid), Ins (inositol). Arrows indicate direction of change. Significant values are bolded. Values are mM.