(A) Representative gel image of serine hydrolase activity in amygdalar tissue collected from non-selected Wistar (W, n=10) and msP (M, n=9) rats. (B) Percentage of spectral counts in active site labeling of the endocannabinoid clearance enzymes fatty acid amide hydrolase (FAAH), monoacylglycerol lipase (MAGL), and α/β-hydrolase domain-containing 6 (ABHD6) in rats from A. (C) Substrate conversion of deuterated N-arachidonoylethanolamine (d4-AEA) into ethanolamine (d4-EA) in amygdalar tissue collected from Wistars (n=8) and msPs (n=8). (D) Velocity of reaction (Vmax) in rats from C. (E) Baseline dialysate concentration of N-arachidonoylethanolamine (anandamide, AEA) in the central nucleus of the amygdala (CeA) of Wistars (n=9) and msPs (n=10). (F) Baseline dialysate concentration of 2-arachidonoylglycerol (2-AG) in the CeA of rats from E. Data expressed as mean ± SEM. Asterisks (*) denote significant genotype differences (p<0.05).