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. 2017 Jul 13;170(2):260–272.e8. doi: 10.1016/j.cell.2017.06.030

Table 1.

Gene Essentiality and Genome Size of Selected Species

Species	Genome Size (Mb)	Protein Coding Genes	Genes Contributing to Normal Growth	%	Assay	Method	Reference
S. cerevisiae	12.1	5,916	1,105 essential	34.9	competitive growth in rich medium	barcoded mutants quantified on nucleotide arrays	Giaever et al., 2002, Deutschbauer et al., 2005
S. cerevisiae	12.1	5,916	962 slow	34.9	competitive growth in rich medium	barcoded mutants quantified on nucleotide arrays	Giaever et al., 2002, Deutschbauer et al., 2005
Trypanosoma brucei	35.0	7,500	2,745	36.6	6-day extracellular blood stream forms in vitro	RNA interference	Alsford et al., 2011
Toxoplasma gondii	63.0	8,158	3,263^b	40.0	intracellular tachyzoites in cultured fibroblasts	CRISPR gRNA screen	Sidik et al., 2016
P. berghei	18.5	4,616^a	2,123^b essential	62.9^b	relative asexual intraerythrocytic growth in vivo	BarSeq	this study
P. berghei	18.5	4,616^a	803^b slow	62.9^b	relative asexual intraerythrocytic growth in vivo	BarSeq	this study

^a

Core genome according to Otto et al. (2014).

^b

Extrapolated from the covered genome.