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. 2017 Jul 13;7:5278. doi: 10.1038/s41598-017-05702-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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KEGG pathway analysis of differentially expressed genes. Advanced bubble chart shows enrichment of differentially expressed genes in signaling pathways. Y-axis label represents pathway, and X-axis label represents rich factor (rich factor = amount of differentially expressed genes enriched in the pathway/amount of all genes in background gene set). Size and color of the bubble represent amount of differentially expressed genes enriched in pathway and enrichment significance, respectively.