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. 2017 Jul 13;7:5338. doi: 10.1038/s41598-017-04439-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The -LN(Mev) is plotted for all possible DOM matches counts, ranging between zero and 51 MS patient matches. The plot is negative for match counts below a total of 20 patients, indicating that a DOM match to 20 patients or less may potentially occur at random. The plot is significantly greater than zero at 30 patient matches, which is our cutoff threshold for DOM categorization.