Table 3.

Toxicities comparison between subgroup.

Toxicities (Grade 3/4)	Adding taxane or not			Taxane-based vs platinum-based				Taxane-based vs epirubicin-based					P value of the interation test
	Study counts	RR	95%CI	P value	Study counts	RR	95%CI	P value	Study counts	RR	95%CI	P value
Neutropenia	5	2.16	0.89–5.21	0.09	3	1.58	0.90–2.77	0.11	2	1.37	1.03–1.82	0.03	0.06
Leukopenia	3	3.61	1.13–11.51	0.03	2	1.67	0.77–3.61	0.19	NM	NM	NM	NM	0.28
Anemia	4	1.28	0.66–2.48	0.47	3	0.76	0.41–1.40	0.38	NM	NM	NM	NM	0.26
Thrombocytopena	4	0.68	0.36–1.27	0.22	2	0.90	0.15–5.46	0.91	2	0.63	0.08–5.00	0.66	0.95
Nausea or vomiting	5	1.36	0.82–2.27	0.24	3	0.40	0.07–2.31	0.31	2	1.22	0.56–2.63	0.62	0.42
Diarrhea	5	1.35	0.64–2.85	0.43	3	1.58	0.57–4.38	0.38	NM	NM	NM	NM	0.81
Febrile neutropenia	3	1.65	0.18–15.14	0.66	NM	NM	NM	NM	NM	NM	NM	NM	—
Anorexia	3	1.50	0.89–2.52	0.13	2	0.85	0.20–3.60	0.82	NM	NM	NM	NM	0.47
Neuropathy & Neurotoxicity	2	3.23	1.41–7.44	0.006	2	0.40	0.15–1.09	0.07	NM	NM	NM	NM	0.002

NM: Not mentioned.