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. 2017 Jul 13;7:5268. doi: 10.1038/s41598-017-05652-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Single cell patch clamp studies demonstrating the effects of flecainide and dofetilide on hESC derived atrial-like CMs. (A) Representative APs during spontaneous firing recorded at baseline and with 10 μM of flecainide demonstrating flecainide-mediated slowing of AP upstroke velocity and prolongation of repolarization. (B) Compared to baseline APs, flecainide resulted in trends towards prolongation of APD30 and APD90 and slowing of the maximum upstroke velocity (n = 10) (C) Representative APs during spontaneous firing recorded at baseline and with 1 μM of dofetilide demonstrating dofetilide-mediated prolongation of repolarization. (D) Compared to baseline APs, dofetilide resulted in prolongation of APD30 and APD90 and slowing of the maximum upstroke velocity (n = 9). APD30 = action potential duration at 30% repolarization, APD90 = action potential duration at 90% repolarization, dV/dt_max = Maximum action potential upstroke velocity NC = No significant change. *p < 0.05, plots show mean ± SEM.