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. 2017 Jul 13;7:5268. doi: 10.1038/s41598-017-05652-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The effects of flecainide on rotor dynamics, APD, CV and CL in atrial-CM sheets. (A) and (B) Show typical activation maps of an atrial-CM sheet in the absence (A) and presence (B) of 10 μM flecainide. Notice the spreading of the activation times when flecainide is present indicating a slowing of the CV. C) shows AP traces, average over the entire sheet) in the absence and presence of 10 μM flecainide. Flecainide did not cause APD prolongation. (D) Presents a histogram of CVs measured at all points in a CM sheet prior to and after the administration of 5 or 10 μM flecainide. Flecainide shifted the histogram distributions of CVs to lower values as a function of drug concentration. (E) Summarizes the CV in 7atrial-CM sheets as a function of flecainide. (F) Shows a summary of the CL for the same sheets and conditions shown Panel (E). APD = action potential duration, CV = conduction velocity, CL = cycle length. *p < 0.05.