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. 2017 Jul 13;7:5268. doi: 10.1038/s41598-017-05652-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The effects of dofetilide on rotor dynamics, APD, and CL in atrial-CM sheets. (A) and (B) Show typical activation maps of an atrial-CM sheet in the absence (A) and presence (B) of 1 μM dofetilide. In this case there is, as with flecainide, a spreading of the activation times consistent with slowing of the CV. (C) Shows AP traces, average over the entire sheet, in the absence and presence of 1 μM dofetilide. Clearly, dofetilide caused notable APD prolongation. (D) Summarizes the APD30 and APD90 for 8 atrial-CM sheets. The data shows that APDs are prolonged following the addition of both 500 nM and 1 μM dofetilide. E demonstrates slowing of the CL in the atrial-CM sheets with increasing doses of dofetilide (n = 8). APD = action potential duration, CV = conduction velocity, CL = cycle length.*p < 0.05, **p < 0.01.