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. 2017 Jul 13;7:5316. doi: 10.1038/s41598-017-05493-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(a) Schematic of the discretization of the potential V_ext along the nerve segment with respect to the nodes of Ranvier. V_ext is determined from integrating the induced electric field calculated in Step 2. Node spacing is assigned based on estimated fiber diameter. (b) Electrical equivalent circuit for the MRG nerve model on each side of a node of Ranvier. Action potentials are created when the transmembrane potential change becomes greater than approximately 20 mV.