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. 2017 Jul 13;7:5270. doi: 10.1038/s41598-017-05560-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Target prediction and validation of miR-30a and Il-1a-3-UTR. (a) Targetscan software showed that miR-30a has a conserved binding site in the Il-1a-3′-UTR in many species including mice and human. (b) Luciferase reporter assay showing miR-30a mimics significantly inhibited the fluorescence values in the pRL-TK-Il-1a-3′-UTR-transfected 293T cells compared to negative controls, which was not the case in the mutated vector (pRL-TK-Il-1a-3′-UTR-mut)-transfected 293T cells. NC, negative controls of miRNA mimics; data are expressed as the Mean ± SD (n = 3); *P < 0.05 vs NC.