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. 2017 Jul 13;7:5270. doi: 10.1038/s41598-017-05560-1

Figure 8.

Figure 8

Endogenous miR-30a and Il-1a mRNA expression levels in PBMC and pancreatic tissues in LPS- and STZ-induced mice assayed by RT-PCR. (a–d) Endogenous miR-30a and Il-1a mRNA expression levels showing a transient increase in PBMCs and pancreatic tissues from LPS (2 mg/kg, ip)-induced mice within 8 h; (e,f) endogenous miR-30a and Il-1a mRNA expression levels showing a significant increase in PBMCs and pancreatic tissues of STZ (100 mg/kg, ip)-induced mice after 4 weeks, but this increase was significantly attenuated by BAY117082 (5 mg/kg, ip), an NFKB inhibitor. Normal, normal control mice; DM, diabetic control mice; and DM+BAY, diabetic mice treated by BAY117082. Data are expressed as the Mean ± SD (n = 6–7); for LPS induced mice, **P < 0.01 for mice after LPS treatment (4 h or 8 h) vs. controls before LPS treatment (0 h) (see 8a–d). For STZ-induced diabetic mice, **P < 0.01 for diabetic control mice vs. normal control mice, and # P < 0.05 and ## P < 0.01 for diabetic mice treated by BAY117802 vs. diabetic control mice (see 8e–h).