Table 1.
Demographics, PCOS features & hormonal characteristics comparison in all study subjects (N = 213).
| Variable | All patients (N = 213) | PCOS (n = 159) | Control (n = 54) | P value |
|---|---|---|---|---|
| Age (y), median (IQR) | 24 (22–28) | 24 (22–29) | 24 (22.8–25.3) | 0.370 |
| Age at menarche (y), median (IQR) | 13 (12–14) | 13(12–14) | 13 (13–14) | 0.582 |
| Height (cm), mean (SD) | 163.96 (6.2) | 163.5 (5.87) | 165.3 (7.0) | 0.067 |
| Weight (kg), mean (SD) | 74.79 (11.85) | 74.73 (11.77) | 74.9 (12.2) | 0.911 |
| BMI, mean (SD) | 27.91 (4.75) | 28 (4.51) | 27.6 (5.4) | 0.644 |
| Waist circumference (cm), mean (SD) | 79.5 (9.46) | 80.49 (9.47) | 76.6 (8.9) | 0.017 |
| Characteristic/Duration of infertility, % (n) | ||||
| >2–4 years | 72.3 (154) | 72.3 (115) | 72.2 (39) | 0.988 |
| 5 or more years | 27.7 (59) | 27.7 (44) | 27.8 (15) | |
| Androgenic alopecia | Yes | 59 (37.1%) | 3 (5.6%) | <0.001 |
| Acanthosis Negricans (AN) | Yes | 45 (28.3%) | 9 (16.7%) | 0.089 |
| mFG score | >8 | 85 (53.5%) | 0 (0.0 %) | <0.001 |
| <8 | 74(46.5%) | 54 (100%) | ||
| Clinical Hyperandrogenism | None | 65 (40.9%) | 52 (96.3%) | <0.001 |
| Hirsutism and/or Acne | 51(32.1%) | 0 (0.0%) | ||
| Hirsutism | 34 (21.4%) | 0 (0.0%) | ||
| Acne | 9 (5.7%) | 2 (3.7%) | ||
| Menstrual cycle regularity | Regular | 52 (32.7%) | 51(94.4%) | <0.001 |
| Oligo/amenorrhea | 107 (67.3%) | 3 (5.6%) | ||
| Ovarian volume in mL | >10 mm3 | 124 (78.0%) | 7 (13.0%) | <0.001 |
| <10 mm3 | 35 (22.0%) | 47 (87.0%) | ||
| Insulin Resistance -IR | <2.5 | 26 (16.4%) | 29 (53.7%) | <0.001 |
| >2.5 | 133 (83.6%) | 25 (46.3%) | ||
| LH/FSH Ratio | ≤2 | 122 (76.7%) | 45 (83.3%) | 0.308 |
| >2 | 37 (23.3%) | 9 (16.7%) | ||
| PCOS (n=159) | Control (n=54) | t-test & P value | ||
| FSH(units per L) Mean | 5.97 | 5.66 | 1.425* | |
| 0.156** | ||||
| COMPUTE FAI=TT/SHBG Mean | 5.35 | 3.93 | 5.982 | |
| 0.000** | ||||
| Fasting Insulin (microunits per mL) | 1733.5*** | <0.001**** | ||
| Fasting Glucose (mg/dL) | 3850.5*** | 0.256**** | ||
| HOMA IR | 1875*** | <0.001**** | ||
| Free Testosterone (ng/dL) | 2132*** | <0.001**** | ||
| Total Testosterone (ng/dL) | 1524.5*** | <0.001**** | ||
| SHBG (nanomoles per L) | 4020*** | 0.484**** | ||
| LH (units per L) | 3102.5*** | <0.001**** | ||
*Parametric test (normal distribution) -**Independent sample Mann-Whitney U t-test ***Grouping Variable: Cases vs. Control, ****Nonparametric test- Mann-Whitney U test.