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. 2017 Jul 13;7:5303. doi: 10.1038/s41598-017-05525-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Doxorubicin release profile of the His-tagged VLNPs at different pH. The release profiles of free doxorubicin (DOX), HisHBcAg nanoparticles conjugated non-covalently with NTA-DOX (HisHBcAg-NTA-DOX) and HisHBcAg nanoparticles conjugated covalently with folic acid (FA) and non-covalently with NTA-DOX (FA-HisHBcAg-NTA-DOX) at pH 5.4 and 7.4. More than 80% of the free DOX was released after 5 h at pH 5.4 and pH 7.4, whereas approximately 80% of the conjugated DOX on HisHBcAg nanoparticles was released after 16 h at pH 5.4. Data are expressed as mean ± standard deviation (n = 3).