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. 2017 Jul 13;7:5329. doi: 10.1038/s41598-017-04326-z

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Lack of active accumulation of a NIS substrate in NIS KO mice. (a) SPECT/CT analysis of 3-month-old female WT and NIS KO mice fed a CD (coronal and sagittal views). WT mice accumulate ^99mTcO₄ ⁻ in the thyroid (T), salivary glands (SG), and stomach (S). NIS KO mice accumulate ^99mTcO₄ ⁻ only in the bladder (B). Images are displayed as % injected dose/cc. (b) Quantitation of ^99mTcO₄ ⁻ in the corresponding dissected organs 3 hours after injection of the isotope (n = 2–3) with gamma well counting. Activity is expressed as % injected dose/gram of tissue. T = thyroid, SG = salivary gland, S = stomach, Blo = blood, B = bladder. *Indicates p < 0.05, ^# p < 0.01.