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. 2017 Jul 13;7:5349. doi: 10.1038/s41598-017-05776-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Correlation analyses at step A5. Row labels instead of probe names are illustrated in display convenience. The corresponding probe names can be found in Supplementary Tables S1 and S2. Bars labeled with A, P and C correspond to the overall scores of A5 accumulation, p-values and classification error rates, respectively. Panel (A) indicates a hierarchical clustering with complete linkage and centered Pearson correlation after z-score transformation of linear expression projections at step A1. Panel (B) contains the correlations reordered by the clustering results of Panel (A). Correlations of the 27 pairs chosen at step A4 are labeled with yellow boxes, of which the most significant pairs are labeled in bold. Panel (C) is also a hierarchical clustering under the same treatment as that of Panel (A), except that it is for each pair of probes.