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. 2017 Jul 13;7:5297. doi: 10.1038/s41598-017-05573-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Qualitative and quantitative analysis of MB cell behaviour in co-culture. (A) Visualisation of the co-culture initiated for 5 days. Morphological assessment of the invading cells was performed (boxed insets a to e and their respective zoomed in versions). (B) Purkinje cell/tumour cell co-culture visualisation 12 days after implantation. (C) Zoomed version of the boxed area in A and its orthogonal view. (D) Volumisation of the tumour clusters in B using Imaris. Graphical representation of the distance of the satellite tumour cells from the tumour cluster 6 (E) and tumour volume (F). Inverted grey scale images show individual channels for better visualisation of cellular structures. a - e are 63x zoomed-in images of the yellow boxed areas. Arrows point to invasive lamellipodia- and filopodia-like protrusions in invading cells.