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. 2017 Jul 13;7:5274. doi: 10.1038/s41598-017-05349-2

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Upstream regulators altered by VSG. (A) Heatmap of differentially express genes between Sham and VSG (left), and upstream regulators from Ingenuity Pathways Analysis (right). (B and C) Identified motifs from reversible chromatin sites that are more (B) or less (C) accessible in Sham compared to Control and VSG. Numbers in parentheses represent p-values of enrichment of motif occurrence in the given set of sequences compared to background, and the percentage of sequences with the motif. (D) Percentage of accessible chromatin site in each group that contained PPARγ:RXR motif (**Indicates p < 0.01, Fisher’s exact test). (E) Fold change (VSG vs Sham) of FAIRE read counts within chromatin sites contain PPARγ:RXR motifs or random chromatin sites (**Indicates p < 0.01, Wilcoxon’s rank-sum test).