Table 5.
Change in health status after 1 year in outpatients, for total group and each identified phenotype
| All outpatients (N = 143) | Phenotype 1 (n = 51) moderate COPD–mild impact health status | Phenotype 2 (n = 31) moderate COPD–high impact health status | Phenotype 3 (n = 61) severe COPD–mild/moderate impact health status | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Baseline | 12 Months | p | Baseline | 12 Months | p | Baseline | 12 Months | p | Baseline | 12 Months | p | |
| Physiological functioning | ||||||||||||
| FEV1% of predicted | 52.0 ± 13.8 | 53.5 ± 14.0 | 0.06 | 60.8 ± 11.5 | 61.2 ± 11.1 | 0.77 | 53.3 ± 12.8 | 53.3 ± 12.5 | 0.99 | 44.7 ± 11.7 | 47.6 ± 13.9 | <0.01 |
| BMI | 25.7 ± 3.9 | 25.9 ± 4.1 | 0.19 | 24.9 ± 3.1 | 25.0 ± 3.3 | 0.35 | 27.1 ± 4.4 | 27.6 ± 4.8 | 0.05 | 25.7 ± 4.1 | 25.7 ± 4.1 | 0.96 |
| Symptoms | ||||||||||||
| Subjective symptoms | 7.1 ± 4.7 | 7.2 ± 4.5 | 0.94 | 4.5 ± 3.4 | 4.9 ± 3.8 | 0.47 | 11.4 ± 3.7 | 10.4 ± 3.5 | 0.23 | 7.1 ± 4.6 | 7.3 ± 4.4 | 0.65 |
| Dyspnoea emotions | 9.7 ± 3.3 | 10.0 ± 3.3 | 0.29 | 9.4 ± 3.2 | 9.1 ± 3.1 | 0.62 | 11.8 ± 3.7 | 11.7 ± 3.8 | 0.87 | 9.0 ± 2.7 | 9.9 ± 2.9 | 0.02 |
| Fatigue | 26.8 ± 11.0 | 29.7 ± 11.4 | <0.01 | 20.9 ± 7.5 | 25.8 ± 9.1 | <0.01 | 39.6 ± 8.9 | 40.3 ± 9.6 | 0.75 | 25.0 ± 9.1 | 27.5 ± 10.8 | 0.04 |
| Functional impairment | ||||||||||||
| Subjective impairment | 9.9 ± 5.0 | 10.3 ± 4.9 | 0.16 | 7.0 ± 2.9 | 8.0 ± 3.3 | 0.02 | 15.8 ± 5.0 | 14.5 ± 4.4 | 0.09 | 9.2 ± 3.8 | 10.3 ± 4.8 | 0.13 |
| Behavioural impairment | 15.2 ± 13.1 | 15.2 ± 14.7 | 0.96 | 8.0 ± 8.0 | 7.9 ± 8.4 | 0.91 | 30.2 ± 12.4 | 29.4 ± 16.6 | 0.80 | 13.3 ± 10.6 | 13.9 ± 12.8 | 0.59 |
| Quality of life | ||||||||||||
| General QoL | 14.0 ± 12.0 | 15.1 ± 12.7 | 0.13 | 9.4 ± 6.0 | 10.5 ± 8.5 | 0.34 | 29.5 ± 13.8 | 28.5 ± 15.6 | 0.54 | 10.0 ± 7.6 | 12.0 ± 9.0 | 0.03 |
| HrQoL | 4.0 ± 1.6 | 4.3 ± 1.7 | 0.09 | 3.2 ± 0.9 | 4.0 ± 1.6 | <0.01 | 6.0 ± 1.6 | 5.5 ± 1.3 | 0.07 | 3.7 ± 1.3 | 3.9 ± 1.8 | 0.39 |
| Satisfaction relations | 3.1 ± 1.4 | 2.9 ± 1.5 | 0.18 | 2.8 ± 1.1 | 2.8 ± 1.6 | 0.80 | 4.4 ± 1.9 | 3.7 ± 1.6 | 0.02 | 2.7 ± 0.9 | 2.7 ± 1.3 | 0.93 |
Data are represented as mean ± SD, p values in bold: significantly different between baseline and after 1 year (paired t test, p < 0.01). Data on exercise capacity were not collected after 1 year
FEV 1 % forced expiratory volume in 1 s, BMI body mass index, VO 2 max maximal oxygen uptake, QoL quality of life, HrQoL health-related quality of life