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. 2017 Jul 14;8:336. doi: 10.3389/fneur.2017.00336

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Copyright © 2017 Teicher, De Col and Messlinger.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Activity of units displayed at 10-min (A) and 2-s intervals (B) normalized to the respective vehicle intervals, and changes after dural administration of sodium sulfide (Na₂S). (A) The whole sample of 10 units showed a tendency of decreased activity without significant change following local application of Na₂S onto the dura mater. The analysis of each single unit (one-way ANOVA at minute intervals) resulted in a significant decrease in neuronal activity in seven units. In this group, the decrease in activity was significant compared to baseline/vehicle (*) intervals (ANOVA with repeated measures). Three units were not inhibited by topical Na₂S. (B) Higher resolution at 2-s intervals showed a short-lasting significant increase in activity between one interval before and the first two intervals after Na₂S application (*) but not after vehicle.