Table 1A.

Fluorescence intensity change over time (trend) was compared between LLO concentrations higher than 0.1 nM and that of 0.1 nM for M1 and M2 from a linear mixed effects model.

Trend analysis of fluorescence increase over time for HeLa cells
	Trend estimate	p-values	95% CI of trend
Dose Effect	2.7087	0.0002	1.2845	4.1328
M1 comparing LLO 2 to 0.1	0.1487	<0.0001	0.09871	0.1986
M1 comparing LLO 1 to 0.1	0.1448	<0.0001	0.09480	0.1947
M1 comparing LLO 0.5 to 0.1	0.1557	<0.0001	0.1058	0.2057
M1 comparing LLO 0.25 to 0.1	0.03857	0.1297	−0.01140	0.08853
M2 comparing LLO 2 to 0.1	0.006204	0.8070	−0.04376	0.05617
M2 comparing LLO 1 to 0.1	0.01519	0.5498	−0.03477	0.06516
M2 comparing LLO 0.5 to 0.1	0.02558	0.3143	−0.02438	0.07554
M2 comparing LLO 0.25 to 0.1	0.01501	0.5546	−0.03495	0.06497

Holm's procedure was used to adjust for multiple comparisons.