Fig. 2.

Rotarod performance. a–c Comparison of the average latency to fall from the rotating drum displayed by wt (n = 10), casp1^−/− (n = 8), and IL-1ra^−/− (n = 12) mice at baseline and 9 months. The differences were calculated for each mouse and expressed as percentage of baseline by using the following formula: [(L9M − LB) / LB] × 100, where “L9M” and “LB” represent the latency to fall at 9 months and baseline, respectively. d Comparison of the average differences between 9 months and baseline for each genotype; the differences were calculated for each mouse and expressed as percentage of baseline by using the following formula: [(L9M − LB) / LB] × 100. For the statistical comparison between two groups (a–c), we employed paired t tests, whereas for the comparison of three groups (d), we performed one-way ANOVA followed by Newman-Keuls post hoc test. ***P < 0.001 vs. wt; **P < 0.01 vs. wt; *P < 0.05 vs. wt; ⁺ P < 0.05 vs. casp1^−/−