Table 3.
Distribution of the patient-reported symptoms associated with chordoma by tumor location
| Symptom | All (n = 327) (%) | Chordoma tumor location | |||||
|---|---|---|---|---|---|---|---|
| Skull base (n = 131) (%) | Mobile spinea (n = 92) (%) | Sacrum or Coccyx (n = 101) (%) | Otherb (n = 3) (%) | P-valuec | |||
| Chronic pain | (n = 123) | 38 | 14 | 57 | 51 | 33 | 0.001 |
| Depression or severe anxiety | (n = 113) | 35 | 35 | 37 | 31 | 67 | 0.489 |
| Chronic fatigue | (n = 110) | 34 | 30 | 39 | 33 | 67 | 0.269 |
| Difficulty walking | (n = 100) | 31 | 7 | 40 | 54 | 67 | 0.001 |
| Balance impairment | (n = 94) | 29 | 33 | 26 | 25 | 67 | 0.205 |
| Difficulty sitting | (n = 85) | 26 | 2 | 20 | 62 | 33 | 0.001 |
| Double vision | (n = 76) | 23 | 56 | 1 | 2 | 0 | 0.001 |
| Sexual dysfunction | (n = 74) | 23 | 15 | 10 | 46 | 0 | 0.001 |
| Limited mobility | (n = 63) | 19 | 3 | 33 | 29 | 0 | 0.001 |
| Urinary incontinence | (n = 52) | 16 | 2 | 2 | 48 | 0 | 0.001 |
| Chronic sinus problems | (n = 46) | 14 | 34 | 1 | 0 | 0 | 0.001 |
| Urinary retention | (n = 46) | 14 | 1 | 3 | 42 | 0 | 0.001 |
| Hearing loss | (n = 44) | 13 | 32 | 1 | 1 | 0 | 0.001 |
| Fecal incontinence | (n = 41) | 13 | 0 | 1 | 40 | 0 | 0.001 |
| Bowel obstruction | (n = 38) | 12 | 2 | 7 | 30 | 0 | 0.001 |
| Other vision problems | (n = 28) | 9 | 16 | 3 | 4 | 0 | 0.002 |
Symptoms were asked using the following survey question: “Which of the following health effects have you ever suffered as a result of chordoma?”
a Includes neck, mid back, and lower back
b Includes extra-axial, multifocal, or unknown
c P-values were calculated using Fisher’s exact test