Figure 3. Female sex is predicted to increase susceptibility to reentrant arrhythmia following acute SNS stimulation in the setting of acquired long‐QT syndrome induced by dofetilide application.

A–B, predicted reentrant wave following SNS on female heterogeneous tissue (5.4 cm × 6.6 cm) containing an endocardial region (tissue columns 1–160) and an epicardial region (tissue columns 161–360) based on recordings from human tissue, and anisotropic conduction in the presence of female hormones during the early follicular (A), late follicular (B) and luteal phases (C) of the menstrual cycle. D, no arrhythmia was predicted in male tissue with 35 nm testosterone. Single APs from site ‘a’ and site ‘b’ in the simulated tissues are shown in the middle panels for each case. Computed electrograms from simulated tissues are shown in the right panels.