Figure 7. Female sex is predicted to increase susceptibility to reentrant arrhythmia following acute SNS stimulation in the setting of inherited LQT2 syndrome.

A–C, predicted reentrant wave following SNS on female heterogeneous tissue (5.4 cm × 6.6 cm) containing an endocardial region (tissue columns 1–160) and an epicardial region (tissue columns 161–360) based on recordings from human tissue, and anisotropic conduction in the presence of female hormones during the early follicular (A), late follicular (B) and luteal (C) phases of the menstrual cycle. D, no arrhythmia was predicted in male tissue with 35 nm testosterone. Computed electrograms from simulated tissues are shown in the right panels.