Fig. 3. 3D structures of representative karyopherin-cargo complex. (A) Structure of importin-α with HIV-1 Tat NLS. (B) Structure of importin-β with RpL4 PY-NLS. (C) Structure of CRM1-Ran-RanBP1 with CPEB4 NES. Indicated number of amino acid residues are the binding sites of each karyopherins. These figures downloaded from RCSB PDB (http://www.rcsb.org/pdb/home/home.do). NLS, nuclear localization signal; PY, proline-tyrosine; NES, nuclear export signal.
