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. 2017 May 3;36(14):2061–2072. doi: 10.15252/embj.201696189

Figure 7. Model for BsHPF‐induced 100S formation.

Figure 7

  • A
    Stress conditions, such as nutrient deprivation, lead to elevated levels of (p)ppGpp, which up‐regulates expression of the LHPF (NTD, green; CTD, red). The LHPF‐CTD can interact to form homodimers in solution and therefore may also be present as dimers in the cell.
  • B
    The long linker of the dimeric LHPF enables the LHPF‐NTD to interact with two independent 70S ribosomes and by bringing them in to close proximity stabilizes the 70S dimers, forming 100S.
  • C–E
    Following removal of the stress conditions, BsHPF levels decline leading to (C) dissociation of 100S into 70S ribosomes and (D) eventually ribosome splitting into 30S and 50S subunits, or (E) alternatively directly in 30S and 50S subunits.