TABLE 1.
Basal values of arterial blood pressure, renal blood flow, and renal excretory function
| Group | N | MAP (mmHg) | GFR (ml/min per g) | RBF (ml/min per g) | UNaV (μmol/min per g) | FENa (%) | V (μl/min per g) |
|---|---|---|---|---|---|---|---|
| I3C-induced rats/untreated | 15 | 179 ± 3* | 1.06 ± 0.28 | 4.59 ± 0.24* | 1.19 ± 0.28 | 1.01 ± 0.24 | 16.18 ± 2.61* |
| I3C-induced rats/EET-A | 16 | 156 ± 4** | 1.17 ± 0.22 | 7.02 ± 0.61 | 1.07 ± 0.24 | 0.98 ± 0.26 | 16.02 ± 2.12* |
| Noninduced rats/untreated | 14 | 114 ± 3 | 1.22 ± 0.25 | 7.81 ± 0.54 | 0.76 ± 0.27 | 0.81 ± 0.22 | 8.92 ± 0.71 |
| Noninduced rats/EET-A | 14 | 115 ± 4 | 1.16 ± 0.19 | 8.04 ± 0.47 | 0.79 ± 0.26 | 0.84 ± 0.23 | 9.22 ± 0.61 |
The pooled data derived from groups under control and experimental protocol. Values are means ± SEM. EET-A, group treated with orally active epoxyeicosatrienoic acid analog; FENa, fractional sodium excretion; GFR, glomerular filtration rate; I3C-induced rats, Cyp1a1-Ren-2 transgenic rats fed the diet containing 0.3% indole-3-carbinol; MAP, mean arterial pressure; Noninduced rats, Cyp1a1-Ren-2 transgenic rats fed the diet without indole-3-carbinol; RBF, renal blood flow; UNa V, sodium excretion; V, urine flow.
*
P < 0.05 versus noninduced rat group.
**
P < 0.05 versus untreated I3C-induced rats.