FIG. 4.

Score changes from baseline at Week 12 (MEM-MD-57A Part 2: Pbo, Mem) and Week 60 or end of study (MEM-MD-67: Pbo/Mem, Mem/Mem) in Children's Communication Checklist, 2nd ed. (CCC-2) Subscales (autism intent-to-treat [ITT] population). In MEM-MD-57A Part 2 the mixed-effect model repeated measures (MMRM) approach based on observed cases was performed, and in MEM-MD-67 only descriptive statistics were analyzed. Therefore, the score changes from baseline are least squares means from MMRM model for MEM-MD-57A Part 2 and ordinary means for MEM-MD-67. *p = 0.02. Mem, extended-release memantine; Pbo, placebo; SEM, standard error of the mean.