Table 2.

Model building summary, base scenario with allometric weight on (V1, V2, CL, Q), sorted by BIC

Additional covariates	–2LL	AIC	BIC	Number of parameters
None	5616	5636	5680	10
CPB (V2, V1)	5609	5633	5686	12
CPB (V2)	5613	5635	5684	11
CBP (V1)	5611	5633	5682	11
CPB (V2, V1), PMA (CL)	5595	5621	5679	13
CPB (V2), PMA (CL)	5600	5624	5677	12
CPB (V1), PMA (CL)	5597	5621	5675	12
PMA (CL)	5602	5624	5673	11
CPB (Q, V2)	5593	5617	5671	12
CPC (Q)	5595	5617	5666	11
CPB (Q, V2, V1)	5582	5608	5666	13
CPB (Q, V2), PMA (CL)	5579	5605	5663	13
CPB (Q, V1)	5584	5608	5662	12
CPB (Q), PMA (CL)	5580	5604	5658	12
CPB (Q, V2, V1), PMA (CL)	5568	5596	5658	14
CPB (Q, V1), PMA (CL)	5570	5596	5653	13
CPB (CL)	5489	5511	5560	11
CPB (Cl), PMA (CL)	5478	5502	5556	12
CPB (V1, CL)	5467	5491	5544	12
CPB (V1, CL), PMA (CL)	5456	5482	5540	13
CPB (V2, CL)	5448	5472	5526	12
CPB (V2, CL), PMA (CL)	5439	5465	5522	13
CPB (V2, V1, CL)	5391	5417	5475	13
CPB (V1, V1, CL), PMA (CL)	5383	5411	5473	14
CBP (Q, V1, CL)	5378	5404	5462	13
CPB (Q, V1, CL), PMA (CL)	5368	5396	5459	14
CPB (Q, CL)	5379	5403	5456	12
CPB (Q, CL), PMA (CL)	5369	5395	5453	13
CPB (Q, V2, V1, CL)	5348	5376	5438	14
CPB (Q, V2, V1, CL), PMA (CL)	5339	5369	5436	15
CPB (Q, V2, CL)	5350	5376	5434	13
CPB (Q, V2, CL), PMA (CL )	5341	5369	5432	14

−2LL, minus two times the log likelihood; weight allometric= bodyweight with theta values fixed to 0.75 (CL, Q) and 1 (V1, V2)

AIC, Akaike information criterion; BIC, Bayesian information criterion; CL, systemic clearance; CPB, cardiopulmonary bypass; PMA, postmenstrual age; Q, intercompartmental clearance; V1, central volume of distribution; V2, peripheral volume of distribution. Bold number, the lowest values for the model quality parameters