Table 2.
Parameter estimates for the final model
| Parameter | Estimates | RSE (%) | 95% CI |
|---|---|---|---|
| Cl/F, l h –1 | 26.3 | 2.48 | 25.0, 27.6 |
| Vc/F, l | 489 | 2.79 | 462, 516 |
| Q/F, l h –1 | 11.8 | 11.4 | 9.18, 14.4 |
| Vp/F, l | 213 | 7.14 | 183, 243 |
| Ka, h –1 | 2.70 | 5.65 | 2.40, 3.00 |
| D1, h | 1.68 | 3.88 | 1.55, 1.81 |
| F1 (fixed for sparse sample) | 1.00 | ||
| Age effect on Cl/F (AGECL): ~(Age/59) AGECL | –0.409 | 13.2 | –0.303, –0.515 |
| WT effect on Cl/F (WTCL): ~(WT/73) WTCL | 0.517 | 17.5 | 0.34, 0.694 |
| WT effect on Vc/F (WTVc): ~(WT/73) WTVc | 0.65 | 17.6 | 0.425, 0.874 |
| IIV in Cl/F, CV% | 53.7 | 3.71 | 49.8, 57.6 |
| IIV in Vc/F, CV% | 61.5 | 4.53 | 56, 66.9 |
| Correlation between IIVs in Cl/F and Vc/F | 0.839 | 2.67 | 0.795, 0.883 |
| IIV in Ka, CV% | 151 | 4.35 | 138, 164 |
| IOV in F1, CV% | 44.6 | 7.99 | 37.6, 51.6 |
| Residual variability for rich profile, CV% | 26.5 | 2.97 | 25.0, 28.1 |
| Residual variability for sparse profile, CV% | 47.3 | 3.67 | 43.9, 50.7 |
CI, confidence interval; CV%, coefficient of variation; IIV, inter‐individual variability; IOV, inter‐occasion variability; RSE, relative standard error