Figure 1.

Diagnostic plots of the pharmacokinetic model: (A) observed vs. population model‐predicted rituximab concentrations; (B) observed vs. individual model‐predicted rituximab concentrations; (C) normalized prediction distribution errors (NPDE) vs. gaussian law; (D) population weighted residuals vs. population predicted rituximab concentrations; (E) individual weighted residuals vs. individual predicted rituximab concentrations; (F) prediction‐corrected visual predictive check; observed concentrations (black circles), theoretical (dashed bold lines) and empirical (continuous thin lines) percentiles (from bottom to top: 10%, 50% and 90% percentiles) and prediction interval (from bottom to top: 10%, 50% and 90% prediction intervals)