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. 2017 Jul 14;4(4):ENEURO.0025-17.2017. doi: 10.1523/ENEURO.0025-17.2017

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Copyright © 2017 Briggs et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 5. — Effects of genotype and treatment on body weight and mortality in PS19 mice. A, Tg mice have lower body weights compared to nTg mice. Daily administration of ISRIB reduced body weight in nTg mice over the course of nine weeks. B, Tg mice have reduced survival rates compared to nTg mice. ISRIB improved survival in nTg mice. nTg vehicle, n = 27; nTg ISRIB, n = 25; Tg vehicle, n = 15; Tg ISRIB, n = 25. Asterisks indicate comparisons to nTg vehicle. Error bars indicate SEM; *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.