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Compound A increases LCAT plasma activity for some LCAT mutations. CER was determined in the plasma of patients with FLD and individuals with fish-eye disease using either (A) the 3H-CER method or (B) the CER enzymatic absorbance method. FLD mutations were T274I, R147W, K218N, and F278S. FED mutations were V46E, Y312C/E354K, and S91P/A141T. Results represent means ± S.D. of at least triplicate measurements. *P < 0.05 compared with the untreated control. FED, fish-eye disease
