Table 2.
Medical outcomes studies of donors assessed in the long term after living liver donation
| First author, year, country, reference | Donor cohort sample size and graft types | Number of study sites | Study design | Enrollment rate | Loss to follow-up (longitudinal studies only) | Years since donation | Long-term (≥1 year postdonation) medical outcomes |
|---|---|---|---|---|---|---|---|
| Muzaale, 2012, USA (18) | 4,111 (996 LLS, 2742 RL, 359 LL) | Not applicable; national cohort of all donors | Donor and matched comparison groups (national samples of living kidney donors and healthy participants from NHANES III) retrospective review of prospectively recorded data | 100% of eligible donors included | No known loss to follow-up; ascertainment utilized multiple databases | Median, 7.6 year Interquartile range, 4.2–10.1 years |
Mortality |
| Adcock, 2010, Canada (23) | 202 (all RL) | 1 | Single group, retrospective review of prospectively recorded data | 100% of eligible donors included | 7% | Mean, 2.8 year, SD, 1.7 Range, 1.0–7.0 years |
Complications by type and Clavien grade |
| Abecassis, 2012, USA (20) | 740 (707 RL, 33 LL) | 9 | Single group, composed of “retrospective” subgroup (enrolled postdonation with retrospective chart review plus prospective data collection thereafter, n = 396) and “prospective” subgroup (enrolled at donation and followed, n = 344) | Not reported | Not reported | Retrospective subgroup: Median, 3.4 years Range, 0.0–10.4 years Prospective subgroup: Median, 1.8 years Range, 0.0–6.9 years |
Complications by type and Clavien grade |
| Castedal, 2010, Sweden (10) | Subset of 24 of 34 enrolled (13 LLS, 11 RL). Subset included donors with known predonation liver volumes | 1 | Single group, cross-sectional follow-up, with comparison to predonation medical records data | For 34 enrolled: 94% of all donors; 97% of those contacted. (Subset of 24 is 69% of donors contacted.) | For 34 enrolled: Mean, 6.0 years Range, 1.0–12.0 years (specific data for n = 24 not provided) |
Liver remnant regeneration based on volumetric analysis of MRI scans | |
| Klink, 2014, Germany (25) | 47 (24 LLS, 18 RL, 5 LL) | 1 | Single group, retrospective review of prospectively recorded data | Not reported | Not reported | Mean, 1.9 years Range, 0.08–7.0 years |
Liver remnant regeneration based on volumetric analysis of MRI or CT scans |
| Murad, 2016, USA (26) |
|
1 | Single group, cross-sectional follow-up, with comparison to predonation medical records data | For 68 enrolled: 70% of eligible donors. Subset of 45 is 46% of eligible donors. Subset of 60 is 62%of eligible donors. | N = 40: Median 6.0 years Range, 1.7–10.9 years N = 60: Median 5.5 year Range 1.5–10.9 years |
Liver remnant regeneration based on volumetric analysis of MRI scans (postdonation) and CT scans (predonation) Liver function and other laboratory tests | |
| Trotter, 2011, USA (28) | 487 (all adult to adult; all RL or LL; exact n’s and/or %s not reported) | 9 | Single group, including donors enrolled postdonation with retrospective chart review plus prospective data collection thereafter, and donors enrolled at donation and followed. | Not reported | Not reported | Range, 0.0–4.0 years | Liver function and other laboratory tests |
| Lei, 2013, China (29) | 300 (7 LLS, 251 RL, 42 LL) | 1 | Single group, retrospective review of prospectively recorded data | 84% | Not reported | Mean 3.7 years Range 0.2–10.8 years |
Liver function and other laboratory tests |
CT, computed tomography; LLS, left lateral segment; RL, right lobe; LL, left lobe; NHANES, National Health and Nutrition Examination Survey.