Figure 2. MetaXcan-predicted association of predicted gene transcript levels with grip strength across biologically relevant tissues in GTEx.

Data are shown for all genes at which altered transcription was significantly associated with grip strength in at least one biologically relevant tissue, after accounting for multiple testing. Data are z-scores of transcript level association with higher handgrip strength, clustered by tissue. Direction of z-score indicates whether higher or lower gene expression is associated with higher grip strength. Absolute z-score>1.96 indicates nominal significance at P≤0.05, and ≥4.94 indicates significance after adjustment for multiple testing (P≤7.91 × 10⁻⁷). NAcc, nucleus accumbens.